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Timestamps:
00:30 My Sleep Results
01:28 Melatonin Anti-Aging Benefits
02:28 Melatonin Dosage
04:51 My Bloodwork Results
06:20 Does Melatonin Suppress Natural Production
07:28 Should I Take Melatonin
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31 responses to “I Took Melatonin Every Day for 3 Months and Here’s What Happened”
Longevity and Anti-Aging Playlist: https://www.youtube.com/watch?v=5KNsfEBXKMg&list=PLMaXsmhvb0r2zcztetf3oE6_zKOm9TebR&ab_channel=SiimLand
Interesting experiment Siim. Did the indirect markers of inflammation — RDW, ESR, ferritin or albumin change at all? Did the trigs/hdl ratio improve, i.e. trigs stay the same or reduce?
Do you think people with autoimmune diseases should avoid melatonine if it boosts the immune system?
Siim, I love your videos. I’m a fan. But have you ever read the Matthew Walker book, “Why we Sleep”. There he emphasizes about his big concern off taking melatonin for sleep. I’m sure in short term it might improve your blood markers, but aren’t you worried about in long term how it could be detrimental to your own body melatonin hormonal production?
I’m sorry for my english, i’m from Brazil.
Love your videos man!
Keep it up!
I addressed it in the video. No evidence it reduces natural production
@@SiimLand You are awesome man. Greetings from Brazil.
0.3 mg was better for me too, than more. Less is more in this case I guess. (30yso)
I’ve been taking10 mg Melatonin for a long time. I sleep very soundly, but, I also look much younger than my years would indicate. (I’m almost 71 and I look like I’m in my 50s.)
Hii Siim, amazing video as always. just a question, do you also use eight sleep pod for better sleep?
I’m a scientist specialist in redox signaling. I would never take any antioxidant as a supplement regularly.
As you mentioned, in this aspect the dosis is the most important aspect, but only followed by the duration of the supplementation.
All non-enzyme antioxidants could act as prooxidants depending on the conditions.
How about taking a precursor such as Tryptophan?
If you take a negligible quantity of anything, then I’d expect negligible results too
there’s no evidence that taking more than 300mcg does anything beneficial in any long term way.
Please review the research of Russel J. Reiter and Doris Loh before you mention the ‘drawbacks’ of high dose melatonin…
Exactly
apparently daily doses b/w 20 and 40 mg significantly helps kill cancer
my sleep notable improved after starting melatoning 10y ago never to deteriorate to the level it was at prior to melatonin.
RAY PEAT: “Okay, you mentioned the hormones estrogen and how it relates to melatonin. With increasing age, people have made a big thing of the fact that melatonin, which peaks about 3AM in everyone, that this peak is a little bit smaller in old age. But it happens that…with aging, as the thyroid decreases, the melatonin decreases, because when thyroid is active, your melatonin comes up as an antioxidant defence against that the high metabolic rate that thyroid can stimulate. So when your thyroid is low, the melatonin is low, when your thyroid is high, the melatonin is high, in a logical adaptation — because it is an antioxidant.
But the function of melatonin all by itself, when it isn’t surrounded by the appropriate other conditions, melatonin, in studies done in pig tissue, by a man named (Sirotkin?), pigs are relatively close to humans in having daytime habits, night time sleep and so on, which is very important for melatonin because it’s a night time dominant hormone — in pigs, he found that melatonin suppresses progesterone and raises estrogen, and this happens to be the same thing that low thyroid does.
So if the melatonin rises in proportion to your thyroid, it doesn’t matter that it is having these pro-estrogen, anti-progesterone effects, because the thyroid is doing exactly the opposite to those hormones and is taking care of the situation, because thyroid gets rid of the excess estrogen while…being totally responsible for producing progesterone. But if you take melatonin out of context, as he did in the pig study, you’re going to get an exactly anti-thyroid effect, deranging those hormones in the direction of stress and aging.
Some of the current publicity that is used to promote the fact that melatonin is used to make you go to sleep, it happens to be also a thing that goes up during hibernation, and its function is to lower the body temperature, and remember the hospitalized patients — the ones who had the lowest temperatures were the least likely to survive, because as the thyroid goes down and your body temperature falls, you lose a lot of your immune functions and tissue repair capacity. So lowering your body temperature does make you hibernate and it does make you sleep, but you don’t want to use something out of context to force that.
The studies that have been used to advocate melatonin’s possibly anti-aging effect were done on mice and rats, and it turns out that they are very opposite to human beings and pigs, because they work at night in general and sleep in the daytime, and so melatonin for them has exactly the opposite meaning that it does for people and pigs. And for example, in humans and rats, melatonin raises prolactin, but in humans, prolactin knocks out progesterone production and causes infertility and stress and osteoporosis for example.
But in rats, it happens, and mice, it happens…prolactin raises their progesterone, and progesterone has the pro-life, anti-aging effect. So melatonin has been confused by a lot of this rodent based research which is opposite in many ways to what it does in people and pigs.” Gary Null interview 1996
Legit?
Ray Peat is DEAD way before his time. I wouldn’t listen to “gurus” who can’t help THEMSELVES first.
There are italian doctors that use melatonin as cancer fighting or preventing supplement. And as a preventive dose they recommend 20 gr 3 times per day. It is a supplement which has also adenosine and glycine in it. Of course melatonin is not the only supplement they use to prevent cancer: they also add vit d, c and other components…
I take 160 mg every night , I wake up feeling younger than I did before I started. More rested and repaired.
20 GRAMS?
@@OpenlyBritishprobably meant 20 mg
Matt Blackburn is taking 200 mg a day.
I’m in my 20s and I’ve been taking 0.3 – 0.6 mg melatonin daily for close to a year and I feel like it helps me fall asleep faster, especially when I’m in a caloric deficit. I haven’t noticed any tolerance or negative side affects like grogginess. I still wake up during the night fairly consistently (usually for the restroom or between sleep cycles), but I’m able to fall back asleep without too much difficulty. I like to combine 0.3 mg short acting and 0.3 mg extended release. I take them both together 1 – 2 hours before bed.
I take 5 mg per night. Sleep has good quality.
I do too, 10-30 mg nothing special happens, I sleep better, but also I am absolutely dependent on it.
I have been taking 1 mg melatonin for a few weeks now and have been sleeping perfectly ever since. I’m in my 40s.
Do you weight it from powder or something full of fillers?
I’d really like to see a video on pharmaceuticals, for example LDL-c lowering drugs.